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Studies & Milestones

November 2021
study
XNUMXth Study

Comparing the anti-aging hallmark activities of Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease.Orli Binyamina, Kati Frida, Guy Keller, Ann Saada, Ruth Gabizon.

For further reading, a scientific article is attached

XNUMXth Study
First clinical trial in humans - finished
XNUMXth Study

The effect of GranaGard on cognitive indices in MS patientsBeneficial effects of a nano formulation of pomegranate seed oil, Granagard®, on the cognitive function in multiple sclerosis patients. P. Petrou MD, A. Ginzberg PhD., O. Binyamin PhD. and D. Karussis MD, PhD.

to read MaMr. ScientificResearch Details – The Ministry of Health’s Clinical Research Website

Presented at the conference of the Israeli Society of Neurology. December

Also presented at the Greek Neuroimmunological Conference, December 2019

September 2020
study
XNUMXth Study

Punica granatum L.-derived omega-5 nanoemulsion improves hepatic steatosis in mice fed a high fat diet by increasing fatty acid utilization in hepatocytesK. Zamora-López, LG Noriega, A. Estanes-Hernández, I. Escalona-Nández, S. Tobón-Cornejo, AR Tovar, V. Barbero-Becerra & C. Pérez-Monter

For further reading, a scientific article is attached

August 2020
study
XNUMXth Study

Delay of gCJD aggravation in sick TgMHu2ME199K mice by combining NPC transplantation and Nano-PSO administration.Neurobiol Aging. 2020 Aug 6;95:231-239. doi: 10.1016/j.neurobiolaging.2020.07.030. Epub ahead of print. PMID: 32861834. Frid K, Binyamin O, Usman A, Gabizon R.

For further reading, a scientific article is attached

December 2019
study
XNUMXth Study

Brain targeting of 9c,11t-conjugated linoleic acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice.Sci Rep. 2019 Dec 5;9(1):18437. doi: 10.1038/s41598-019-54971-9. Erratum in: Sci Rep. 2020 Jan 23;10(1):1320. PMID: 31804596; PMCID: PMC6895090. Binyamin O, Nitzan K, Frid K, Ungar Y, Rosenmann H, Gabizon R.

For further reading, a scientific article is attached

אפריל 2019
study
XNUMXth Study

Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?Neurobiol Dis. 2019 Apr;124:57-66. doi: 10.1016/j.nbd.2018.11.003. Epub 2018 Nov 10. PMID: 30423473. Keller G, Binyamin O, Frid K, Saada A, Gabizon R.For further reading, a scientific article is attached

December 2018
patent
European patent EP2844265A1 (pending)

Thanks to the unique development based on the most advanced "nano technology" in the world today, GranaGard will be granted a European patent.

 
December 2018
patent
US patent US10154961

Thanks to the unique development based on the most advanced “nanotechnology” in the world today, GranaGard has been granted a U.S. patent.

 
December 2017
study
XNUMXrd Study

Continues administration of Nano-PSO significantly increased survival of genetic CJD mice.Neurobiol Dis. 2017 Dec;108:140-147. doi: 10.1016/j.nbd.2017.08.012. Epub 2017 Aug 25. PMID: 28847567. Binyamin O, Keller G, Frid K, Larush L, Magdassi S, Gabizon R.For further reading, a scientific article is attached

January 2017
Beginning of marketing
US patent US10154961
Granguard Nano Omega 5

Development of Granguard nano-omega 5 and start of marketing

The only dietary supplement in the world that contains omega-5 antioxidants

November 2015
study
XNUMXnd Study

Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant.International Journal of Nanomedicine. 2015:10. 7165—7174. 10.2147/IJN.S92704. Binyamin, Orli & Larush, Liraz & Arush, & Frid, Kati & Keller, Guy & Friedman-Levi, Yael & Ovadia, Haim & Abramsky, Oded & Magdass, Shlomo & Gabizon, Ruth. (2015).For further reading, a scientific article is attached

2014
study
XNUMXst Study

Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD.

Nanomedicine. 2014 Aug;10(6):1353-63. doi: 10.1016/j.nano.2014.03.015. Epub 2014 Apr 2. PMID: 24704590. Mizrahi M, Friedman-Levi Y, Larush L, Frid K, Binyamin O, Dori D, Fainstein N, Ovadia H, Ben-Hur T, Magdassi S, Gabizon R.

For further reading, a scientific article is attached

May 2013
Establishment of the company

GRANALIX is a biotechnology start-up company, founded by Professor Ruth Gabizon – senior researcher from the Department of Neurology at Hadassah University Hospital, Jerusalem – together with Professor Shlomo Magdassi, an international expert in the field of Nanotechnology from the Casali Center, Institute of Chemistry, at the Hebrew University of Jerusalem.

2022 © Granlix Bio Technologies Ltd.

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